期刊
NATURE NANOTECHNOLOGY
卷 12, 期 10, 页码 1006-1014出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/NNANO.2017.133
关键词
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资金
- National Research Foundation of Korea - Ministry of Education, Science, and Technology [NRF-2017M3A9C6029306, 2016R1A2B2014195, 2013M3A9B4076483, NRF-2015 M3A9B4051064]
- Ministry of Health Welfare [HI16C1176]
- Rural Development Administration [PJ011077]
- Ministry of Food and Drug Safety [14172MFDS974]
- National Research Foundation of Korea [2015M3A9B4051064, 2017M3A9C6029312, 2016R1A2B2014195, 2013M3A9B4076483] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Electromagnetic fields (EMF) are physical energy fields generated by electrically charged objects, and specific ranges of EMF can influence numerous biological processes, which include the control of cell fate and plasticity. In this study, we show that electromagnetized gold nanoparticles (AuNPs) in the presence of specific EMF conditions facilitate an efficient direct lineage reprogramming to induced dopamine neurons in vitro and in vivo. Remarkably, electromagnetic stimulation leads to a specific activation of the histone acetyltransferase Brd2, which results in histone H3K27 acetylation and a robust activation of neuron-specific genes. In vivo dopaminergic neuron reprogramming by EMF stimulation of AuNPs efficiently and non-invasively alleviated symptoms in mouse Parkinson's disease models. This study provides a proof of principle for EMF-based in vivo lineage conversion as a potentially viable and safe therapeutic strategy for the treatment of neurodegenerative disorders.
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