期刊
NATURE METHODS
卷 14, 期 4, 页码 399-+出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nmeth.4178
关键词
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资金
- Howard Hughes Medical Institute
- HHMI
- NIH [1R01-AG029430, R01GM120292, R01DK102495, BioXFEL-STC1231306]
- DOE [DE-FC02-02ER63421]
Traditionally, crystallographic analysis of macromolecules has depended on large, well-ordered crystals, which often require significant effort to obtain. Even sizable crystals sometimes suffer from pathologies that render them inappropriate for high-resolution structure determination. Here we show that fragmentation of large, imperfect crystals into microcrystals or nanocrystals can provide a simple path for high-resolution structure determination by the cryoEM method MicroED and potentially by serial femtosecond crystallography.
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