期刊
NATURE MEDICINE
卷 23, 期 11, 页码 1258-1270出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nm.4430
关键词
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资金
- MRC
- Wellcome Trust
- Royal Society
- MRC [MR/L008289/1] Funding Source: UKRI
- Medical Research Council [MR/L008289/1] Funding Source: researchfish
Macrophages are found throughout the body, where they have crucial roles in tissue development, homeostasis and remodeling, as well as being sentinels of the innate immune system that can contribute to protective immunity and inflammation. Barrier tissues, such as the intestine, lung, skin and liver, are exposed constantly to the outside world, which places special demands on resident cell populations such as macrophages. Here we review the mounting evidence that although macrophages in different barrier tissues may be derived from distinct progenitors, their highly specific properties are shaped by the local environment, which allows them to adapt precisely to the needs of their anatomical niche. We discuss the properties of macrophages in steady-state barrier tissues, outline the factors that shape their differentiation and behavior and describe how macrophages change during protective immunity and inflammation.
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