期刊
NATURE MEDICINE
卷 23, 期 3, 页码 279-287出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nm.4294
关键词
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资金
- Canadian Institutes of Health Research
- Alberta Innovates Health Solutions
- Heart and Stroke Foundation of Canada
- Canada Research Chairs program
The production of neutrophil extracellular traps (NETs) is a process that enables neutrophils to help catch and kill bacteria. However, increasing evidence suggests that this process might also occur in noninfectious, sterile inflammation. In this Review, we describe the role of NETosis in autoimmunity, coagulation, acute injuries and cancer, and discuss NETs as potential therapeutic targets. Furthermore, we consider whether extracellular DNA is always detrimental in sterile inflammation and whether the source is always NETs.
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