期刊
NATURE GENETICS
卷 50, 期 1, 页码 130-+出版社
NATURE PORTFOLIO
DOI: 10.1038/s41588-017-0008-5
关键词
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资金
- Biotechnology and Biological Sciences Research Council (BBSRC) David Phillips Fellowship [BB/L025043/1]
- BBSRC [BB/M01973X/1]
- Sainsbury PhD Studentship
- Biotechnology and Biological Sciences Research Council [BBS/E/J/000PR9773, BBS/E/J/000C0675, BB/L025043/1] Funding Source: researchfish
- BBSRC [BBS/E/J/000PR9773, BB/L025043/1, BBS/E/J/000C0675] Funding Source: UKRI
DNA methylation regulates eukaryotic gene expression and is extensively reprogrammed during animal development. However, whether developmental methylation reprogramming during the sporophytic life cycle of flowering plants regulates genes is presently unknown. Here we report a distinctive gene-targeted RNA-directed DNA methylation (RdDM) activity in the Arabidopsis thaliana male sexual lineage that regulates gene expression in meiocytes. Loss of sexual-lineage-specific RdDM causes mis-splicing of the MPS1 gene (also known as PRD2), thereby disrupting meiosis. Our results establish a regulatory paradigm in which de novo methylation creates a cell-lineage-specific epigenetic signature that controls gene expression and contributes to cellular function in flowering plants.
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