期刊
NATURE GENETICS
卷 49, 期 12, 页码 1664-1670出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/ng.3969
关键词
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资金
- Office of the Director of the US National Institutes of Health (NIH)
- National Cancer Institute (NCI)
- National Human Genome Research Institute (NHGRI)
- National Heart, Lung, and Blood Institute (NHLBI)
- National Institute on Drug Abuse (NIDA)
- National Institute of Mental Health (NIMH)
- National Institute of Neurological Disorders and Stroke (NINDS)
- Leidos [10ST1035, HHSN261200800001E]
- Hewlett-Packard Stanford Graduate Fellowship
- Natural Science and Engineering Council of Canada
- NIH [U01MH104393, U01HG007598, U01HG007599, U01HG007593, U01HG007591, U01HG007610, U01HG007601, U01HL131042]
- Leidos Biomedical
- [HHSN268201000029C]
- [DA006227]
Genetic variants have been associated with myriad molecular phenotypes that provide new insight into the range of mechanisms underlying genetic traits and diseases. Identifying any particular genetic variant's cascade of effects, from molecule to individual, requires assaying multiple layers of molecular complexity. We introduce the Enhancing GTEx (eGTEx) project that extends the GTEx project to combine gene expression with additional intermediate molecular measurements on the same tissues to provide a resource for studying how genetic differences cascade through molecular phenotypes to impact human health.
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