期刊
NATURE GENETICS
卷 49, 期 6, 页码 913-+出版社
NATURE PORTFOLIO
DOI: 10.1038/ng.3847
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资金
- ATIP-Avenir (CNRS/ INSERM)
- Fondation ARC pour la Recherche sur le Cancer [PJA20151203273, PDF20150602803, PDF20140601375]
- Marie Curie Career Integration Grants [322035]
- Agence Nationale de la Recherche [ANR-16-CE12-0019, ANR-13-BSV6-0006-01, ANR-11-LABX-0028-01]
- Canceropole PACA (AAP)
- DuPont
- Wellcome Trust [WT098051]
- Vetenskapsradet (Swedish Research Council) [325-2014-4605]
- Labex SIGNALIFE program from Agence Nationale de la Recherche [ANR-11-LABX-0028-01]
- Agence Nationale de la Recherche (ANR) [ANR-13-BSV6-0006, ANR-16-CE12-0019] Funding Source: Agence Nationale de la Recherche (ANR)
Structural rearrangements have long been recognized as an important source of genetic variation, with implications in phenotypic diversity and disease, yet their detailed evolutionary dynamics remain elusive. Here we use long-read sequencing to generate end-to-end genome assemblies for 12 strains representing major subpopulations of the partially domesticated yeast Saccharomyces cerevisiae and its wild relative Saccharomyces paradoxus. These population-level high-quality genomes with comprehensive annotation enable precise definition of chromosomal boundaries between cores and subtelomeres and a high-resolution view of evolutionary genome dynamics. In chromosomal cores, S. paradoxus shows faster accumulation of balanced rearrangements (inversions, reciprocal translocations and transpositions), whereas S. cerevisiae accumulates unbalanced rearrangements (novel insertions, deletions and duplications) more rapidly. In subtelomeres, both species show extensive interchromosomal reshuffling, with a higher tempo in S. cerevisiae. Such striking contrasts between wild and domesticated yeasts are likely to reflect the influence of human activities on structural genome evolution.
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