期刊
NATURE GENETICS
卷 49, 期 5, 页码 789-+出版社
NATURE PORTFOLIO
DOI: 10.1038/ng.3823
关键词
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资金
- US National Institutes of Health (NIH) [R01CA139020, R01CA52689, P30CA125123]
- McNair Medical Institute
- Population Sciences Biorepository at Baylor College of Medicine
- Acta Oncologica through the Royal Swedish Academy of Science
- Swedish Research Council
- Swedish Cancer Foundation
- Cancer Research UK - Bobby Moore Fund [C1298/A8362]
- Wellcome Trust
- DJ Fielding Medical Research Trust
- National Cancer Research Network
- European Union [QLK4-CT-1999-01563]
- International Union against Cancer (UICC)
- Mobile Manufacturers' Forum
- GSM Association
- UICC
- Mobile Telecommunications and Health Research (MTHR) Programme
- Health and Safety Executive, Department of Health and Safety Executive
- UK Network Operators
- Ligue Nationale Contre le Cancer
- Fondation ARC
- Institut National du Cancer (INCa) [PL046]
- French Ministry of Higher Education and Research
- program Investissements d'avenir [ANR-10-IAIHU-06]
- Genome Quebec
- le Ministere de l'Enseignement superieur, de la Recherche, de la Science et de la Technologie (MESRST) Quebec
- McGill University
- Deutsche Forschungsgemeinschaft [Si552, Schr285]
- Deutsche Krebshilfe [70-2385-Wi2, 70-3163-Wi3, 10-6262]
- BONFOR
- Wellcome Trust [076113, 085475]
- German Federal Ministry of Education and Research (BMBF)
- Helmholtz Zentrum Munchen
- German Research Center for Environmental Health, Neuherberg
- German National Genome Research Network (NGFN)
- Munich Center of Health Sciences (MC Health) as part of LMUinnovativ
- German Federal Ministry of Education and Research (BMBF) through the Integrated Network IntegraMent (Integrated Understanding of Causes and Mechanisms in Mental Disorders) - e:Med research and funding concept [01ZX1314A]
- DFG
- Alfried Krupp von Bohlen und Halbach-Stiftung
- BONFOR Programme of the University of Bonn, Germany
- NIH [R01CA139020, R01CA52689, P50CA097257, R01CA126831, P50CA108961, P30CA15083]
- Loglio Collective
- National Brain Tumor Foundation
- Stanley D. Lewis and Virginia S. Lewis Endowed Chair in Brain Tumor Research
- Robert Magnin Newman Endowed Chair in Neuro-oncology
- National Center for Research Resources
- National Center for Advancing Translational Sciences, NIH, through UCSF-CTSI [UL1 RR024131]
- National Cancer Institute's Surveillance, Epidemiology and End Results Program [HHSN261201000140C, HHSN261201000035C, HHSN261201000034C]
- Centers for Disease Control and Prevention's National Program of Cancer Registries [U58DP003862-01]
- National Institute of Neurological Disorders and Stroke [RC1NS068222Z]
- Bernie and Edith Waterman Foundation
- Ting Tsung and Wei Fong Chao Family Foundation
Genome-wide association studies (GWAS) have transformed our understanding of glioma susceptibility, but individual studies have had limited power to identify risk loci. We performed a meta-analysis of existing GWAS and two new GWAS, which totaled 12,496 cases and 18,190 controls. We identified five new loci for glioblastoma (GBM) at 1p31.3 (rs12752552; P = 2.04 x 10(-9), odds ratio (OR) = 1.22), 11q14.1 (rs11233250; P = 9.95 x 10(-10), OR = 1.24), 16p13.3 (rs2562152; P = 1.93 x 10-8, OR = 1.21), 16q12.1 (rs10852606; P = 1.29 x 10(-11), OR = 1.18) and 22q13.1 (rs2235573; P = 1.76 x 10(-10), OR = 1.15), as well as eight loci for non-GBM tumors at 1q32.1 (rs4252707; P = 3.34 x 10(-9), OR = 1.19), 1q44 (rs12076373; P = 2.63 x 10(-10), OR = 1.23), 2q33.3 (rs7572263; P = 2.18 x 10(-10), OR = 1.20), 3p14.1 (rs11706832; P = 7.66 x 10(-9), OR = 1.15), 10q24.33 (rs11598018; P = 3.39 x 10-8, OR = 1.14), 11q21 (rs7107785; P = 3.87 x 10(-10), OR = 1.16), 14q12 (rs10131032; P = 5.07 x 10(-11), OR = 1.33) and 16p13.3 (rs3751667; P = 2.61 x 10(-9), OR = 1.18). These data substantiate that genetic susceptibility to GBM and non-GBM tumors are highly distinct, which likely reflects different etiology.
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