期刊
NATURE CHEMICAL BIOLOGY
卷 13, 期 8, 页码 833-+出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nchembio.2393
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资金
- ETH Zurich
- University of Minnesota
- Swiss National Science Foundation [31003A_146992]
- EU (SYNPEPTIDE)
- Swiss National Science Foundation (SNF) [31003A_146992] Funding Source: Swiss National Science Foundation (SNF)
Peptide backbone N-methylation, as seen in cyclosporin A, has been considered to be exclusive to nonribosomal peptides. We have identified the first post-translationally modified peptide or protein harboring internal alpha-N-methylations through dis-covery of the genetic locus for the omphalotins, cyclic N-methylated peptides produced by the fungus Omphalotus olearius. We show that iterative autocatalytic activity of an N-methyltransferase fused to its peptide substrate is the signature of a new family of ribosomally encoded metabolites. The fidelity and complexity of
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