期刊
NATURE CHEMICAL BIOLOGY
卷 13, 期 4, 页码 360-+出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nchembio.2301
关键词
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资金
- Total New Energies
- Novo Nordisk Foundation
- Knut and Alice Wallenberg Foundation
- National Natural Science Foundation of China [21325627]
- NNF Center for Biosustainability [Yeast Cell Factories] Funding Source: researchfish
- Novo Nordisk Fonden [NNF10CC1016517] Funding Source: researchfish
Fungal type I fatty acid synthases (FASs) are mega-enzymes with two separated, identical compartments, in which the acyl carrier protein (ACP) domains shuttle substrates to catalytically active sites embedded in the chamber wall. We devised synthetic FASs by integrating heterologous enzymes into the reaction chambers and demonstrated their capability to convert acyl-ACP or acyl-CoA from canonical fatty acid biosynthesis to short/ medium-chain fatty acids and methyl ketones.
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