相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。Development of secondary mutations in wild-type and mutant EZH2 alleles cooperates to confer resistance to EZH2 inhibitors
V. Gibaja et al.
ONCOGENE (2016)
Relationship between Tumor Biomarkers and Efficacy in EMILIA, a Phase III Study of Trastuzumab Emtansine in HER2-Positive Metastatic Breast Cancer
Jose Baselga et al.
CLINICAL CANCER RESEARCH (2016)
Quantitative Profiling of Combinational K27/K36 Modifications on Histone H3 Variants in Mouse Organs
Yanyan Yu et al.
JOURNAL OF PROTEOME RESEARCH (2016)
Structural basis for activity regulation of MLL family methyltransferases
Yanjing Li et al.
NATURE (2016)
Structural basis of oncogenic histone H3K27M inhibition of human polycomb repressive complex 2
Neil Justin et al.
NATURE COMMUNICATIONS (2016)
Polycomb repressive complex 2 structure with inhibitor reveals a mechanism of activation and drug resistance
Alexei Brooun et al.
NATURE COMMUNICATIONS (2016)
Ezh2 loss in hematopoietic stem cells predisposes mice to develop heterogeneous malignancies in an Ezh1-dependent manner
Makiko Mochizuki-Kashio et al.
BLOOD (2015)
Structural basis of histone H3K27 trimethylation by an active polycomb repressive complex 2
Lianying Jiao et al.
SCIENCE (2015)
EPZ011989, A Potent, Orally-Available EZH2 Inhibitor with Robust in Vivo Activity
John E. Campbell et al.
ACS MEDICINAL CHEMISTRY LETTERS (2015)
Selective Inhibition of EZH2 by EPZ-6438 Leads to Potent Antitumor Activity in EZH2-Mutant Non-Hodgkin Lymphoma
Sarah K. Knutson et al.
MOLECULAR CANCER THERAPEUTICS (2014)
Targeting MLL1 H3K4 Methyltransferase Activity in Mixed-Lineage Leukemia
Fang Cao et al.
MOLECULAR CELL (2014)
Synergistic blockade of mitotic exit by two chemical inhibitors of the APC/C
Katharine L. Sackton et al.
NATURE (2014)
Recurrent point mutations in the kinetochore gene KNSTRN in cutaneous squamous cell carcinoma
Carolyn S. Lee et al.
NATURE GENETICS (2014)
Discovery and Optimization of Tetramethylpiperidinyl Benzamides as Inhibitors of EZH2
Christopher G. Nasveschuk et al.
ACS MEDICINAL CHEMISTRY LETTERS (2014)
An Orally Bioavailable Chemical Probe of the Lysine Methyltransferases EZH2 and EZH1
Kyle D. Konze et al.
ACS CHEMICAL BIOLOGY (2013)
A liquid chromatography/mass spectrometry-based generic detection method for biochemical assay and hit discovery of histone methyltransferases
Shu Li et al.
ANALYTICAL BIOCHEMISTRY (2013)
Small-molecule inhibition of MLL activity by disruption of its interaction with WDR5
Guillermo Senisterra et al.
BIOCHEMICAL JOURNAL (2013)
Identification of EZH2 and EZH1 Small Molecule Inhibitors with Selective Impact on Diffuse Large B Cell Lymphoma Cell Growth
Shivani Garapaty-Rao et al.
CHEMISTRY & BIOLOGY (2013)
Structure of the Arginine Methyltransferase PRMT5-MEP50 Reveals a Mechanism for Substrate Specificity
Meng-Chiao Ho et al.
PLOS ONE (2013)
EZH2 Mediates Epigenetic Silencing of Neuroblastoma Suppressor Genes CASZ1, CLU, RUNX3, and NGFR
Chunxi Wang et al.
CANCER RESEARCH (2012)
On WD40 proteins Propelling our knowledge of transcriptional control?
Valentina Migliori et al.
EPIGENETICS (2012)
A687V EZH2 is a gain-of-function mutation found in lymphoma patients
Christina R. Majer et al.
FEBS LETTERS (2012)
Lapatinib with trastuzumab for HER2-positive early breast cancer (NeoALTTO): a randomised, open-label, multicentre, phase 3 trial
Jose Baselga et al.
LANCET (2012)
EZH2 inhibition as a therapeutic strategy for lymphoma with EZH2-activating mutations
Michael T. McCabe et al.
NATURE (2012)
Genetic inactivation of the polycomb repressive complex 2 in T cell acute lymphoblastic leukemia
Panagiotis Ntziachristos et al.
NATURE MEDICINE (2012)
Mutation of A677 in histone methyltransferase EZH2 in human B-cell lymphoma promotes hypertrimethylation of histone H3 on lysine 27 (H3K27)
Michael T. McCabe et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)
Crystal structure of the human PRMT5:MEP50 complex
Stephen Antonysamy et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)
Selective inhibition of Ezh2 by a small molecule inhibitor blocks tumor cells proliferation
Wei Qi et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)
REFMAC5 for the refinement of macromolecular crystal structures
Garib N. Murshudov et al.
ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY (2011)
Somatic mutations at EZH2 Y641 act dominantly through a mechanism of selectively altered PRC2 catalytic activity, to increase H3K27 trimethylation
Damian B. Yap et al.
BLOOD (2011)
H3K36 Methylation Antagonizes PRC2-mediated H3K27 Methylation
Wen Yuan et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2011)
Structure and function of WD40 domain proteins
Chao Xu et al.
PROTEIN & CELL (2011)
Analysis of the Binding of Mixed Lineage Leukemia 1 (MLL1) and Histone 3 Peptides to WD Repeat Domain 5 (WDR5) for the Design of Inhibitors of the MLL1-WDR5 Interaction
Hacer Karatas et al.
JOURNAL OF MEDICINAL CHEMISTRY (2010)
Somatic mutations of the histone methyltransferase gene EZH2 in myelodysplastic syndromes
Gorica Nikoloski et al.
NATURE GENETICS (2010)
Somatic mutations altering EZH2 (Tyr641) in follicular and diffuse large B-cell lymphomas of germinal-center origin
Ryan D. Morin et al.
NATURE GENETICS (2010)
Inactivating mutations of the histone methyltransferase gene EZH2 in myeloid disorders
Thomas Ernst et al.
NATURE GENETICS (2010)
Binding of different histone marks differentially regulates the activity and specificity of polycomb repressive complex 2 (PRC2)
Chao Xu et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
Coordinated activities of wild-type plus mutant EZH2 drive tumor-associated hypertrimethylation of lysine 27 on histone H3 (H3K27) in human B-cell lymphomas
Christopher J. Sneeringer et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
WD40 proteins propel cellular networks
Christian U. Stirnimann et al.
TRENDS IN BIOCHEMICAL SCIENCES (2010)
Role of the polycomb protein EED in the propagation of repressive histone marks
Raphael Margueron et al.
NATURE (2009)
A polycomb repression signature in metastatic prostate cancer predicts cancer outcome
Jindan Yu et al.
CANCER RESEARCH (2007)
Structural basis of EZH2 recognition by EED
Zhifu Han et al.
STRUCTURE (2007)
Chromatin modifications and their function
Tony Kouzarides
CELL (2007)
The functions of E(Z)/EZH2-mediated methylation of lysine 27 in histone H3
R Cao et al.
CURRENT OPINION IN GENETICS & DEVELOPMENT (2004)
SUZ12 is required for both the histone methyltransferase activity and the silencing function of the EED-EZH2 complex
R Cao et al.
MOLECULAR CELL (2004)
Coot:: model-building tools for molecular graphics
P Emsley et al.
ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY (2004)
EZH2 is downstream of the pRB-E2F pathway, essential for proliferation and amplified in cancer
AP Bracken et al.
EMBO JOURNAL (2003)
分享论文
