相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。The PI3K/AKT Pathway as a Target for Cancer Treatment
Ingrid A. Mayer et al.
ANNUAL REVIEW OF MEDICINE, VOL 67 (2016)
Phase I Study of an AKT Inhibitor (MK-2206) Combined with Lapatinib in Adult Solid Tumors Followed by Dose Expansion in Advanced HER2+ Breast Cancer
Kari B. Wisinski et al.
CLINICAL CANCER RESEARCH (2016)
Large-Scale Analysis of Breast Cancer-Related Conformational Changes in Proteins Using Limited Proteolysis
Fang Liu et al.
JOURNAL OF PROTEOME RESEARCH (2016)
Upregulation of AKT3 Confers Resistance to the AKT Inhibitor MK2206 in Breast Cancer
Casey Stottrup et al.
MOLECULAR CANCER THERAPEUTICS (2016)
The LINK-A lncRNA activates normoxic HIF1α signalling in triple-negative breast cancer
Aifu Lin et al.
NATURE CELL BIOLOGY (2016)
3D tumor spheroid models for in vitro therapeutic screening: a systematic approach to enhance the biological relevance of data obtained
Michele Zanoni et al.
SCIENTIFIC REPORTS (2016)
Measurement of PIP3 Levels Reveals an Unexpected Role for p110β in Early Adaptive Responses to p110α-Specific Inhibitors in Luminal Breast Cancer
Carlotta Costa et al.
CANCER CELL (2015)
A Cytoplasmic NF-κB Interacting Long Noncoding RNA Blocks IκB Phosphorylation and Suppresses Breast Cancer Metastasis
Bodu Liu et al.
CANCER CELL (2015)
PDK1-mTOR signaling pathway inhibitors reduce cell proliferation in MK2206 resistant neuroblastoma cells
Lei Qi et al.
CANCER CELL INTERNATIONAL (2015)
Global Analysis of the RNA-Protein Interaction and RNA Secondary Structure Landscapes of the Arabidopsis Nucleus
Sager J. Gosai et al.
MOLECULAR CELL (2015)
Screening for Small-Molecule Modulators of Long Noncoding RNA-Protein Interactions Using AlphaScreen
Roya Pedram Fatemi et al.
JOURNAL OF BIOMOLECULAR SCREENING (2015)
IncRNA Directs Cooperative Epigenetic Regulation Downstream of Chemokine Signals
Zhen Xing et al.
CELL (2014)
Mutational Landscape of the Essential Autophagy Gene BECN1 in Human Cancers
Saurabh V. Laddha et al.
MOLECULAR CANCER RESEARCH (2014)
Global analysis of protein structural changes in complex proteomes
Yuehan Feng et al.
NATURE BIOTECHNOLOGY (2014)
PI3K and cancer: lessons, challenges and opportunities
David A. Fruman et al.
NATURE REVIEWS DRUG DISCOVERY (2014)
The STAT3-Binding Long Noncoding RNA lnc-DC Controls Human Dendritic Cell Differentiation
Pin Wang et al.
SCIENCE (2014)
The RNA-Binding Protein DDX1 Promotes Primary MicroRNA Maturation and Inhibits Ovarian Tumor Progression
Cecil Han et al.
CELL REPORTS (2014)
Targeting Bruton's tyrosine kinase in B cell malignancies
Rudi W. Hendriks et al.
NATURE REVIEWS CANCER (2014)
Pressure-assisted sample preparation for proteomic analysis
Pawel P. Olszowy et al.
ANALYTICAL BIOCHEMISTRY (2013)
Improved proteomic profiling of the cell surface of culture-expanded human bone marrow multipotent stromal cells
Samuel T. Mindaye et al.
JOURNAL OF PROTEOMICS (2013)
Structural basis for RNA recognition by a dimeric PPR-protein complex
Jiyuan Ke et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2013)
Synaptic PI(3,4,5)P3 Is Required for Syntaxin1A Clustering and Neurotransmitter Release
Thang Manh Khuong et al.
NEURON (2013)
Lipid binding by the Unique and SH3 domains of c-Src suggests a new regulatory mechanism
Yolanda Perez et al.
SCIENTIFIC REPORTS (2013)
A phase 1 study evaluating the combination of an allosteric AKT inhibitor (MK-2206) and trastuzumab in patients with HER2-positive solid tumors
Clifford Hudis et al.
BREAST CANCER RESEARCH (2013)
mrhl RNA, a Long Noncoding RNA, Negatively Regulates Wnt Signaling through Its Protein Partner Ddx5/p68 in Mouse Spermatogonial Cells
Gayatri Arun et al.
MOLECULAR AND CELLULAR BIOLOGY (2012)
MS2-TRAP (MS2-tagged RNA affinity purification): Tagging RNA to identify associated miRNAs
Je-Hyun Yoon et al.
METHODS (2012)
Segregation of PIP2 and PIP3 into distinct nanoscale regions within the plasma membrane
Jie Wang et al.
BIOLOGY OPEN (2012)
Development of sulfonamide AKT PH domain inhibitors
Ali Md Ahad et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2011)
First-in-Man Clinical Trial of the Oral Pan-AKT Inhibitor MK-2206 in Patients With Advanced Solid Tumors
Timothy A. Yap et al.
JOURNAL OF CLINICAL ONCOLOGY (2011)
Frequent mutations of chromatin remodeling genes in transitional cell carcinoma of the bladder
Yaoting Gui et al.
NATURE GENETICS (2011)
MK-2206, an Allosteric Akt Inhibitor, Enhances Antitumor Efficacy by Standard Chemotherapeutic Agents or Molecular Targeted Drugs In vitro and In vivo
Hiroshi Hirai et al.
MOLECULAR CANCER THERAPEUTICS (2010)
In vivo detection of RNA-binding protein interactions with cognate RNA sequences by fluorescence resonance energy transfer
Martina Huranova et al.
RNA (2009)
Perifosine: Update on a Novel Akt Inhibitor
Joell J. Gills et al.
CURRENT ONCOLOGY REPORTS (2009)
Comprehensive identification of PIP3-regulated PH domains from C elegans to H sapiens by model prediction and live imaging
Wei Sun Park et al.
MOLECULAR CELL (2008)
Lipid signalling in disease
Matthias P. Wymann et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2008)
AKT/PKB signaling: Navigating downstream
Brendan D. Manning et al.
CELL (2007)
Scan of human genome reveals no new loci under ancient balancing selection
K. L. Bubb et al.
GENETICS (2006)
EGF-ERBB signalling: towards the systems level
Ami Citri et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2006)
Specific RNA binding to ordered phospholipid bilayers
Tadeusz Janas et al.
NUCLEIC ACIDS RESEARCH (2006)
Perturbations of the AKT signaling pathway in human cancer
DA Altomare et al.
ONCOGENE (2005)
Electrostatic sequestration of PIP2 on phospholipid membranes by basic/aromatic regions of proteins
A Gambhir et al.
BIOPHYSICAL JOURNAL (2004)
Akt/protein kinase B signaling inhibitor-2, a selective small molecule inhibitor of Akt signaling with antitumor activity in cancer cells overexpressing Akt
L Yang et al.
CANCER RESEARCH (2004)
Targeting the PI3K-Akt pathway in human cancer: Rationale and promise
J Luo et al.
CANCER CELL (2003)
Binding of phosphatidylinositol 3,4,5-trisphosphate to the pleckstrin homology domain of protein kinase B induces a conformational change
CC Milburn et al.
BIOCHEMICAL JOURNAL (2003)
High-resolution structure of the pleckstrin homology domain of protein kinase B/Akt bound to phosphatidylinositol (3,4,5)-trisphosphate
CC Thomas et al.
CURRENT BIOLOGY (2002)
The phosphatidylinositol 3-kinase-AKT pathway in human cancer
I Vivanco et al.
NATURE REVIEWS CANCER (2002)
Protein-RNA interactions: a structural analysis
S Jones et al.
NUCLEIC ACIDS RESEARCH (2001)
Characterization of Rny1, the Saccharomyces cerevisiae member of the T2 RNase family of RNases:: Unexpected functions for ancient enzymes?
GC MacIntosh et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)
Crystal structure of the ribonucleoprotein core of the signal recognition particle
RT Batey et al.
SCIENCE (2000)
分享论文
