期刊
NATURE CELL BIOLOGY
卷 19, 期 4, 页码 384-+出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/ncb3486
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资金
- National Institutes of Health [GM69429]
- National Institutes of Health Fellowship [F32GM105099]
- American Cancer Society Fellowship [PF1409901CCG]
- NIH [GM118396]
- Burroughs Wellcome Career Award
Microtubules tether centrosomes together during interphasel. How this is accomplished and what benefit it provides to the cell is not known. We have identified a bipolar, minus-end-directed kinesin, Kif25, that suppresses centrosome separation. Kif25 is required to prevent premature centrosome separation during interphase. We show that premature centrosome separation leads to microtubule-dependent nuclear translocation, culminating in eccentric nuclear positioning that disrupts the cortical spindle positioning machinery. The activity of Kif25 during interphase is required to maintain a centred nucleus to ensure the spindle is stably oriented at the onset of mitosis.
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