期刊
NATURE CELL BIOLOGY
卷 19, 期 7, 页码 758-760出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/ncb3566
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The mechanism of action of oncogenes in acute myeloid leukaemia is poorly understood. A study now shows that the fusion oncoprotein AML1-ETO regulates leukaemogenesis by increasing the expression of small nucleolar RNAs through post-transcriptional mechanisms, resulting in increased ribosomal RNA methylation, protein translation, and promotion of leukaemic-cell self-renewal and growth.
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