相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。Attacking cancer's Achilles heel: antagonism of antiapoptotic BCL-2 family members
Joseph T. Opferman
FEBS JOURNAL (2016)
A Network of Conserved Synthetic Lethal Interactions for Exploration of Precision Cancer Therapy
Rohith Srivas et al.
MOLECULAR CELL (2016)
Systematic comparison of CRISPR/Cas9 and RNAi screens for essential genes
David W. Morgens et al.
NATURE BIOTECHNOLOGY (2016)
Parallel shRNA and CRISPR-Cas9 screens enable antiviral drug target identification
Richard M. Deans et al.
NATURE CHEMICAL BIOLOGY (2016)
Multiplexed barcoded CRISPR-Cas9 screening enabled by CombiGEM
Alan S. L. Wong et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)
Sources of Error in Mammalian Genetic Screens
Laura Magill Sack et al.
G3-GENES GENOMES GENETICS (2016)
Thirty years of BCL-2: translating cell death discoveries into novel cancer therapies
Alex R. D. Delbridge et al.
NATURE REVIEWS CANCER (2016)
Synthetic Lethality and Cancer Therapy: Lessons Learned from the Development of PARP Inhibitors
Christopher J. Lord et al.
ANNUAL REVIEW OF MEDICINE, VOL 66 (2015)
Genome-wide CRISPR Screen in a Mouse Model of Tumor Growth and Metastasis
Sidi Chen et al.
CELL (2015)
A Genome-wide CRISPR Screen in Primary Immune Cells to Dissect Regulatory Networks
Oren Parnas et al.
CELL (2015)
Massively parallel high-order combinatorial genetics in human cells
Alan S. L. Wong et al.
NATURE BIOTECHNOLOGY (2015)
Boosting CRISPR/Cas9 multiplex editing capability with the endogenous tRNA-processing system
Kabin Xie et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)
Gene essentiality and synthetic lethality in haploid human cells
Vincent A. Blomen et al.
SCIENCE (2015)
Potent and selective small-molecule MCL-1 inhibitors demonstrate on-target cancer cell killing activity as single agents and in combination with ABT-263 (navitoclax)
J. D. Leverson et al.
CELL DEATH & DISEASE (2015)
Rapid and efficient one-step generation of paired gRNA CRISPR-Cas9 libraries
Joana A. Vidigal et al.
NATURE COMMUNICATIONS (2015)
The BioGRID interaction database: 2015 update
Andrew Chatr-aryamontri et al.
NUCLEIC ACIDS RESEARCH (2015)
STRING v10: protein-protein interaction networks, integrated over the tree of life
Damian Szklarczyk et al.
NUCLEIC ACIDS RESEARCH (2015)
Genome-Scale CRISPR-Mediated Control of Gene Repression and Activation
Luke A. Gilbert et al.
CELL (2014)
Dimeric CRISPR RNA-guided Fokl nucleases for highly specific genome editing
Shengdar Q. Tsai et al.
NATURE BIOTECHNOLOGY (2014)
Functional genomics platform for pooled screening and generation of mammalian genetic interaction maps
Martin Kampmann et al.
NATURE PROTOCOLS (2014)
The IUPHAR/BPS Guide to PHARMACOLOGY: an expert-driven knowledgebase of drug targets and their ligands
Adam J. Pawson et al.
NUCLEIC ACIDS RESEARCH (2014)
Easy quantitative assessment of genome editing by sequence trace decomposition
Eva K. Brinkman et al.
NUCLEIC ACIDS RESEARCH (2014)
Genome-Scale CRISPR-Cas9 Knockout Screening in Human Cells
Ophir Shalem et al.
SCIENCE (2014)
Maturation Stage of T-cell Acute Lymphoblastic Leukemia Determines BCL-2 versus BCL-XL Dependence and Sensitivity to ABT-199
Triona Ni Chonghaile et al.
CANCER DISCOVERY (2014)
The PIM family of oncoproteins: small kinases with huge implications in myeloid leukemogenesis and as therapeutic targets
Kumar Saurabh et al.
ONCOTARGET (2014)
The BCL2 inhibitor ABT-199 significantly enhances imatinib-induced cell death in chronic myeloid leukemia progenitors
Tun Kiat Ko et al.
ONCOTARGET (2014)
Synthetic Lethal Interaction of Combined BCL-XL and MEK Inhibition Promotes Tumor Regressions in KRAS Mutant Cancer Models
Ryan B. Corcoran et al.
CANCER CELL (2013)
Dynamic Imaging of Genomic Loci in Living Human Cells by an Optimized CRISPR/Cas System
Baohui Chen et al.
CELL (2013)
A Systematic Mammalian Genetic Interaction Map Reveals Pathways Underlying Ricin Susceptibility
Michael C. Bassik et al.
CELL (2013)
The translocator protein (TSPO): A novel target for cancer chemotherapy
Christopher J. D. Austin et al.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2013)
Quantitative genetic-interaction mapping in mammalian cells
Assen Roguev et al.
NATURE METHODS (2013)
Citron kinase controls a molecular network required for midbody formation in cytokinesis
Zuni I. Bassi et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)
Integrated platform for genome-wide screening and construction of high-density genetic interaction maps in mammalian cells
Martin Kampmann et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)
A Tumor Suppressor Complex with GAP Activity for the Rag GTPases That Signal Amino Acid Sufficiency to mTORC1
Liron Bar-Peled et al.
SCIENCE (2013)
RNA-Guided Human Genome Engineering via Cas9
Prashant Mali et al.
SCIENCE (2013)
Multiplex Genome Engineering Using CRISPR/Cas Systems
Le Cong et al.
SCIENCE (2013)
High-Throughput Methods for Combinatorial Drug Discovery
Xiaochen Sun et al.
SCIENCE TRANSLATIONAL MEDICINE (2013)
Therapeutic Targeting of a Robust Non-Oncogene Addiction to PRKDC in ATM-Defective Tumors
Arina Riabinska et al.
SCIENCE TRANSLATIONAL MEDICINE (2013)
Cdc25A promotes cell survival by stimulating NF-κB activity through IκB-α phosphorylation and destabilization
Hey-Young Hong et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2012)
Functional Repurposing Revealed by Comparing S-pombe and S-cerevisiae Genetic Interactions
Adam Frost et al.
CELL (2012)
Synthetic lethal targeting of DNA double-strand break repair deficient cells by human apurinic/apyrimidinic endonuclease inhibitors
Rebeka Sultana et al.
INTERNATIONAL JOURNAL OF CANCER (2012)
Unresponsiveness of colon cancer to BRAF(V600E) inhibition through feedback activation of EGFR
Anirudh Prahallad et al.
NATURE (2012)
Combinatorial drug therapy for cancer in the post-genomic era
Bissan Al-Lazikani et al.
NATURE BIOTECHNOLOGY (2012)
Therapeutic target database update 2012: a resource for facilitating target-oriented drug discovery
Feng Zhu et al.
NUCLEIC ACIDS RESEARCH (2012)
Genome-wide functional screen identifies a compendium of genes affecting sensitivity to tamoxifen
Ana M. Mendes-Pereira et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)
A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity
Martin Jinek et al.
SCIENCE (2012)
Genome-Wide RNAi Screens Identify Genes Required for Ricin and PE Intoxications
Dimitri Moreau et al.
DEVELOPMENTAL CELL (2011)
Seeking the causes and solutions to imatinib-resistance in chronic myeloid leukemia
D. Bixby et al.
LEUKEMIA (2011)
The Polycomb complex PRC2 and its mark in life
Raphael Margueron et al.
NATURE (2011)
Mapping of signaling networks through synthetic genetic interaction analysis by RNAi
Thomas Horn et al.
NATURE METHODS (2011)
Mannosidase 2, alpha 1 Deficiency Is Associated with Ricin Resistance in Embryonic Stem (ES) Cells
Wei Wang et al.
PLOS ONE (2011)
Rewiring of Genetic Networks in Response to DNA Damage
Sourav Bandyopadhyay et al.
SCIENCE (2010)
A survey of the anti-apoptotic Bcl-2 subfamily expression in cancer types provides a platform to predict the efficacy of Bcl-2 antagonists in cancer therapy
W. J. Placzek et al.
CELL DEATH & DISEASE (2010)
Systematic Mapping of Genetic Interaction Networks
Scott J. Dixon et al.
ANNUAL REVIEW OF GENETICS (2009)
From information to knowledge: new technologies for defining gene function
Sean R. Collins et al.
NATURE METHODS (2009)
Mechanisms of drug combinations: interaction and network perspectives
Jia Jia et al.
NATURE REVIEWS DRUG DISCOVERY (2009)
Comprehensive Characterization of Genes Required for Protein Folding in the Endoplasmic Reticulum
Martin C. Jonikas et al.
SCIENCE (2009)
Ultrafast and memory-efficient alignment of short DNA sequences to the human genome
Ben Langmead et al.
GENOME BIOLOGY (2009)
Phosphatidylinositol 3-Kinase Hyperactivation Results in Lapatinib Resistance that Is Reversed by the mTOR/Phosphatidylinositol 3-Kinase Inhibitor NVP-BEZ235
Pieter J. A. Eichhorn et al.
CANCER RESEARCH (2008)
Tracing the Retrograde Route in Protein Trafficking
Ludger Johannes et al.
CELL (2008)
Pim-1 and Pim-2 kinases are required for efficient pre-B-cell transformation by v-Abl oncogene
Ji-Long Chen et al.
BLOOD (2008)
Functional dissection of protein complexes involved in yeast chromosome biology using a genetic interaction map
Sean R. Collins et al.
NATURE (2007)
A functional RNAi screen for regulators of receptor tyrosine kinase and ERK signalling
Adam Friedman et al.
NATURE (2006)
DrugBank: a comprehensive resource for in silico drug discovery and exploration
David S. Wishart et al.
NUCLEIC ACIDS RESEARCH (2006)
A strategy for extracting and analyzing large-scale quantitative epistatic interaction data
Sean R. Collins et al.
GENOME BIOLOGY (2006)
Exploration of the function and organization of the yeast early secretory pathway through an epistatic miniarray profile
M Schuldiner et al.
CELL (2005)
Identification of mcl-1 as a BCR/ABL-dependent target in chronic myeloid leukemia (CML):: evidence for cooperative antileukemic effects of imatinib and mcl-1 antisense oligonucleotides
KJ Aichberger et al.
BLOOD (2005)
A large-scale RNAi screen in human cells identifies new components of the p53 pathway
K Berns et al.
NATURE (2004)
A Bcr/Abl-independent, Lyn-dependent form of imatinib mesylate (STI-571) resistance is associated with altered expression of Bcl-2
Y Dai et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Drug repositioning: Identifying and developing new uses for existing drugs
TT Ashburn et al.
NATURE REVIEWS DRUG DISCOVERY (2004)
Java Treeview-extensible visualization of microarray data
AJ Saldanha
BIOINFORMATICS (2004)
Advances in protein kinase B signalling:: AKTion on multiple fronts
DP Brazil et al.
TRENDS IN BIOCHEMICAL SCIENCES (2004)
Cytoscape: A software environment for integrated models of biomolecular interaction networks
P Shannon et al.
GENOME RESEARCH (2003)