期刊
RUSSIAN JOURNAL OF GENERAL CHEMISTRY
卷 88, 期 12, 页码 2611-2615出版社
MAIK NAUKA/INTERPERIODICA/SPRINGER
DOI: 10.1134/S107036321812023X
关键词
benzothiazole; NSC 710305; proxazole; anticancer activity
A novel series of bis-1,2,4-oxadiazole fused benzothiazole derivatives 9a-9j are synthesized, and their structures are confirmed by H-1 and C-13 NMR, and mass spectral data. All products are evaluated in vitro for their anticancer potential against a panel of four human cancer cell lines such as lung cancer (A549), breast carcinoma (MCF-7), melanoma (A375), and colon cancer (HT-29). The combretastatin-A4 is used as standard drug. All compounds 9a-9j exhibit significant anticancer activity with IC50 values ranging from 0.11 +/- 0.01 to 14.6 +/- 3.89 M. Among these, compounds 9a-9d, 9h, 9i demonstrate more potent activity than the control.
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