期刊
NATURE
卷 542, 期 7640, 页码 177-185出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nature21363
关键词
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资金
- National Institutes of Health [DK052539, HL125753, Al116901]
- JDRF [2SRA-2016-147-Q-R]
- Union Chemique Belge
- Servier
Proper regulation and management of energy, substrate diversity and quantity, as well as macromolecular synthesis and breakdown processes, are fundamental to cellular and organismal survival and are paramount to health. Cellular and multicellular organization are defended by the immune response, a robust and critical system through which self is distinguished from non-self, pathogenic signals are recognized and eliminated, and tissue homeostasis is safeguarded. Many layers of evolutionarily conserved interactions occur between immune response and metabolism. Proper maintenance of this delicate balance is crucial for health and has important implications for many pathological states such as obesity, diabetes, and other chronic non-communicable diseases.
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