相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。The Extracellular Surface of the GLP-1 Receptor Is a Molecular Trigger for Biased Agonism
Denise Wootten et al.
CELL (2016)
Structural Determinants of Binding the Seven-transmembrane Domain of the Glucagon-like Peptide-1 Receptor (GLP-1R)
Dehua Yang et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2016)
Positive Allosteric Modulation of the Glucagon-like Peptide-1 Receptor by Diverse Electrophiles
Ana B. Bueno et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2016)
Structure of the adenosine A2A receptor bound to an engineered G protein
Byron Carpenter et al.
NATURE (2016)
Extra-helical binding site of a glucagon receptor antagonist
Ali Jazayeri et al.
NATURE (2016)
In vitro expression and analysis of the 826 human G protein-coupled receptors
Xuechen Lv et al.
PROTEIN & CELL (2016)
Glucagon-Like Peptide-1 and Its Class B G Protein-Coupled Receptors: A Long March to Therapeutic Successes
Chris de Graaf et al.
PHARMACOLOGICAL REVIEWS (2016)
Functional elements of the gastric inhibitory polypeptide receptor: Comparison between secretin- and rhodopsin-like G protein-coupled receptors
Arnau Cordomi et al.
BIOCHEMICAL PHARMACOLOGY (2015)
Two disparate ligand-binding sites in the human P2Y1 receptor
Dandan Zhang et al.
NATURE (2015)
Structural-Functional Analysis of the Third Transmembrane Domain of the Corticotropin-releasing Factor Type 1 Receptor ROLE IN ACTIVATION AND ALLOSTERIC ANTAGONISM
Katerina Spyridaki et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2014)
Docking Covalent Inhibitors: A Parameter Free Approach To Pose Prediction and Scoring
Kai Zhu et al.
JOURNAL OF CHEMICAL INFORMATION AND MODELING (2014)
High-resolution structure of the human GPR40 receptor bound to allosteric agonist TAK-875
Ankita Srivastava et al.
NATURE (2014)
A potentiator of orthosteric ligand activity at GLP-1R acts via covalent modification
Whitney M. Nolte et al.
NATURE CHEMICAL BIOLOGY (2014)
Insights into the structure of class B GPCRs
Kaspar Hollenstein et al.
TRENDS IN PHARMACOLOGICAL SCIENCES (2014)
GROMACS 4.5: a high-throughput and highly parallel open source molecular simulation toolkit
Sander Pronk et al.
BIOINFORMATICS (2013)
The design and synthesis of a potent glucagon receptor antagonist with favorable physicochemical and pharmacokinetic properties as a candidate for the treatment of type 2 diabetes mellitus
Angel Guzman-Perez et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2013)
Protein and ligand preparation: parameters, protocols, and influence on virtual screening enrichments
G. Madhavi Sastry et al.
JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN (2013)
Structure of class B GPCR corticotropin-releasing factor receptor 1
Kaspar Hollenstein et al.
NATURE (2013)
Structure of the human glucagon class B G-protein-coupled receptor
Fai Yiu Siu et al.
NATURE (2013)
Molecular signatures of G-protein-coupled receptors
A. J. Venkatakrishnan et al.
NATURE (2013)
Polar transmembrane interactions drive formation of ligand-specific and signal pathway-biased family B G protein-coupled receptor conformations
Denise Wootten et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)
A hydrophobic site on the GLP-1 receptor extracellular domain orients the peptide ligand for signal transduction
James T. Patterson et al.
MOLECULAR METABOLISM (2013)
Exploiting structure similarity in refinement: automated NCS and target-structure restraints in BUSTER
Oliver S. Smart et al.
ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY (2012)
Extension of the CHARMM general force field to sulfonyl-containing compounds and its utility in biomolecular simulations
Wenbo Yu et al.
JOURNAL OF COMPUTATIONAL CHEMISTRY (2012)
Discovery of a Novel Glucagon Receptor Antagonist N-[(4-{(1S)-1-[3-(3, 5-Dichlorophenyl)-5-(6-methoxynaphthalen-2-yl)-1H-pyrazol-1-yl]ethyl}phenyl)carbonyl]-β-alanine (MK-0893) for the Treatment of Type II Diabetes
Yusheng Xiong et al.
JOURNAL OF MEDICINAL CHEMISTRY (2012)
Targeting the glucagon receptor family for diabetes and obesity therapy
Young Min Cho et al.
PHARMACOLOGY & THERAPEUTICS (2012)
Fusion Partner Toolchest for the Stabilization and Crystallization of G Protein-Coupled Receptors
Eugene Chun et al.
STRUCTURE (2012)
Crystal structure of the β2 adrenergic receptor-Gs protein complex
Soren G. F. Rasmussen et al.
NATURE (2011)
MolProbity: all-atom structure validation for macromolecular crystallography
Vincent B. Chen et al.
ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY (2010)
XDS
Wolfgang Kabsch
ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY (2010)
Features and development of Coot
P. Emsley et al.
ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY (2010)
PHENIX: a comprehensive Python-based system for macromolecular structure solution
Paul D. Adams et al.
ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY (2010)
Novel Small Molecule Glucagon-Like Peptide-1 Receptor Agonist Stimulates Insulin Secretion in Rodents and From Human Islets
Kyle W. Sloop et al.
DIABETES (2010)
Crystal Structure of Glucagon-like Peptide-1 in Complex with the Extracellular Domain of the Glucagon-like Peptide-1 Receptor
Christina Rye Underwood et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
Update of the CHARMM All-Atom Additive Force Field for Lipids: Validation on Six Lipid Types
Jeffery B. Klauda et al.
JOURNAL OF PHYSICAL CHEMISTRY B (2010)
Functional coupling of Cys-226 and Cys-296 in the glucagon-like peptide-1 (GLP-1) receptor indicates a disulfide bond that is close to the activation pocket
Rosalind J. Mann et al.
PEPTIDES (2010)
Rastering strategy for screening and centring of microcrystal samples of human membrane proteins with a sub-10 μm size X-ray synchrotron beam
Vadim Cherezov et al.
JOURNAL OF THE ROYAL SOCIETY INTERFACE (2009)
P-LINCS: A parallel linear constraint solver for molecular simulation
Berk Hess
JOURNAL OF CHEMICAL THEORY AND COMPUTATION (2008)
Crystal structure of opsin in its G-protein-interacting conformation
Patrick Scheerer et al.
NATURE (2008)
Phaser crystallographic software
Airlie J. McCoy et al.
JOURNAL OF APPLIED CRYSTALLOGRAPHY (2007)
A nonpeptidic agonist of glucagon-like peptide 1 receptors with efficacy in diabetic db/db mice
Desu Chen et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Small-molecule agonists for the glucagon-like peptide 1 receptor
Lotte Bjerre Knudsen et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
New β-alanine derivatives are orally available glucagon receptor antagonists
Jesper Lau et al.
JOURNAL OF MEDICINAL CHEMISTRY (2007)
Canonical sampling through velocity rescaling
Giovanni Bussi et al.
JOURNAL OF CHEMICAL PHYSICS (2007)
REFMAC5 dictionary:: organization of prior chemical knowledge and guidelines for its use
AA Vagin et al.
ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY (2004)