期刊
NATURE
卷 546, 期 7660, 页码 656-+出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nature22815
关键词
-
资金
- JPB's Foundation
- William F. Richter's Foundation
- Michael J. Fox's Foundation
- Parkinson's Foundation
- NIH/NINDS [P50 NS38377]
- NIA [ADRC P50AG005146]
- AHMMRF Parkinson's disease program [M-2014]
- JHH Parkinson's disease program [M-2014]
- JHUSOM Parkinson's disease program [M-2014]
Genetic studies have shown the association of Parkinson's disease with alleles of the major histocompatibility complex(1-3). Here we show that a defined set of peptides that are derived from a-synuclein, a protein aggregated in Parkinson's disease(4), act as antigenic epitopes displayed by these alleles and drive helper and cytotoxic T cell responses in patients with Parkinson's disease. These responses may explain the association of Parkinson's disease with specific major histocompatibility complex alleles.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据