期刊
NATURAL PRODUCT RESEARCH
卷 32, 期 6, 页码 662-667出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/14786419.2017.1335730
关键词
Aspergillus sydowii; antibacterial activities; MRSA; MRSE; alkaloid
资金
- Fundamental Research Funds for the Central Universities [JKZD2013017]
- Project Program of National Natural Science Foundation of China for Young Scientists [81001395]
- Priority Academic Program Development of Jiangsu Higher Education Institutions
- Qing Lan Project
One new alkaloid, named as acremolin C (1), was isolated from static culture of Antarctic fungus, Aspergillus sydowii SP-1, in an investigation of the antimicrobial constituents of this Antarctic microorganism, and its structure was determined by spectroscopic methods. Additionally, four known compounds, cyclo-(L-Trp-L-Phe) (2), 4-hydroxyphenylacetic acid (3), (7S)-(+)-hydroxysydonic acid (4) and (7S, 11S)-(+)-12-hydroxysydonic acid (5), were isolated and identified. Biological studies disclosed that compounds 2, 4 and 5 showed moderate inhibitions against methicillin-resistant Staphylococcus aureus (MRSA) and methicillin-resistant Staphylococcus epidermidis (MRSE) as comparing to tigecycline, while compound 1 displayed weak inhibition activities against MRSA and MRSE.
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