期刊
NATURAL PRODUCT RESEARCH
卷 31, 期 23, 页码 2783-2787出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/14786419.2017.1292506
关键词
Medicinal plant; Myotoxicity; Neurotoxicity; Snake venom
资金
- PROSUP-CAPES
- PROBIC-UNISO
- FAPESP [04/09705-8, 07/53883-6, 08/52643-4, 12/08271-0]
The ability of Terminalia fagifolia hydroalcoholic extract (Tf-HE) to neutralise the paralysis and myotoxicity induced by Bothrops jararacussu venom was assayed using mouse phrenic nerve-diaphragm (PND) preparation and two varieties of chick biventer cervicis (BC) preparations. Tf-HE 100 mu g/mL and 500 mu g/mL were tested against 40 and 200 mu g of venom/mL in PND and BC preparations, respectively, using pre-and post-venom incubation treatments. The effects of Tf-HE against the myotoxicity caused by venom were evaluated via histological analysis (PND) and creatine kinase (CK) release (BC). Tf-HE was able to reverse the venom paralysis in both preparation types. The contractures to exogenous ACh in BC preparations showed that Tf-HE may act on extrinsic, preserving those intrinsic postsynaptic receptors. There was a positive correlation between CK and morphological changes. The high non-hemolytic saponin content can explain the Tf-HE efficacy against the toxic effects of B. jararacussu venom in vertebrate neuromuscular preparations. [GRAPHICS] .
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