期刊
NATURAL PRODUCT RESEARCH
卷 32, 期 18, 页码 2147-2151出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/14786419.2017.1367781
关键词
Calophyllum teysmannii; ananixanthone; modification; cytotoxic; cancer
资金
- Universiti Putra Malaysia (UPM) under the PUTRA research grant
- Fundamental Research Grant Scheme from Ministry of Higher Education (MOHE) [FRGS/1/2015/SG01/TAYLOR/03/1]
Two naturally occurring xanthones, ananixanthone (1) and -mangostin (2), were isolated using column chromatographic method from the n-hexane and methanol extracts of Calophyllum teysmannii, respectively. The major constituent, ananixanthone (1), was subjected to structural modifications via acetylation, methylation and benzylation yielding four new xanthone derivatives, ananixanthone monoacetate (3), ananixanthone diacetate (4), 5-methoxyananixanthone (5) and 5-O-benzylananixanthone (6). Compound 1 together with its four new derivatives were subjected to MTT assay against three cancer cell lines; SNU-1, K562 and LS174T. The results indicated that the parent compound has greater cytotoxicity capabilities against SNU-1 and K562 cell lines with IC50 values of 8.97 +/- 0.11 and 2.96 +/- 0.06g/mL, respectively. Compound 5 on the other hand exhibited better cytotoxicity against LS174T cell line with an IC50 value of 5.76 +/- 1.07g/mL. [GRAPHICS] .
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