期刊
NATURAL PRODUCT RESEARCH
卷 33, 期 10, 页码 1415-1422出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/14786419.2017.1419231
关键词
Pentacyclic guanidine alkaloids; marine sponge; cytotoxic activity; apoptosis
资金
- Russian Science Foundation [17-14-01065]
- Russian Foundation for Basic Research [16-03-00553]
- Russian Science Foundation [17-14-01065] Funding Source: Russian Science Foundation
A new pentacyclic guanidine alkaloid, monanchoxymycalin C (1) was isolated from a new collection of marine sponge Monanchora pulchra along with the known monanchoxymycalin A (2). The structure of 1 was elucidated on the basis of spectroscopic data. Monanchoxymycalin C exhibits cytotoxic activity against human cancer HeLa cells at low micromolar concentrations, induces apoptosis-related death of malignant cells and inhibits cancer cell colony formation. In addition, synergistic and additive effects have been observed in combination with cisplatin.
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