期刊
NATURAL PRODUCT RESEARCH
卷 31, 期 23, 页码 2712-2718出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/14786419.2017.1292270
关键词
Poaceae; adlay; Coix lacrymajobi; melanogenesis; coixol; 9-beta-D-glucopyranosyl adenine
资金
- Egyptian Government
An adenine derivative, 9-beta-D-glucopyranosyl adenine, reported for the first time from a natural source, in addition to nine known compounds were isolated from the seeds of Coix lacryma-jobi. Their structures were elucidated based on extensive spectroscopic and chemical studies. The isolated compounds and the ethanol extract have been assayed for melanin inhibition using B16-F10 melanoma cell line. The results of our study suggested the potential use of Coix lacryma-jobi seeds as a skin whitening agent and reveal the seeds to be a rich source of important phytochemicals with melanogenesis inhibitory activity. Among the isolated compounds, coixol (2) and 2-O-beta-glucopyranosyl-7-methoxy-2H-1,4-benzoxazin-3(4H)-one (8) exhibited potent melanogenesis inhibitory activity with no obvious melanocytotoxicity. The rest of the compounds showed weak to moderate activity. [GRAPHICS] .
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