期刊
NATURAL PRODUCT RESEARCH
卷 32, 期 7, 页码 773-776出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/14786419.2017.1359177
关键词
Scopulariopsis sp.; dihydroquinolin-2(1H)-one; alkaloids; marine natural products; antifouling activity
资金
- Programme of National Natural Science Foundation of China [41606172, 41322037]
- Programme of Natural Science Foundation of Shandong Province of China [JQ201510]
- Marine Special Public Welfare Scientific Research, State Oceanic Administration of China [201405038]
- Qingdao National Laboratory for Marine Science and Technology [2015ASTP-ES11]
- Taishan Scholars Programme, China
- AoShan Talents Programme
Further chemical investigation of the secondary metabolites of the fungus Scopulariopsis sp. led to the discovery of a new alkaloid, scopuquinolone B (1). The structure of compound 1 was elucidated by extensive NMR spectroscopic data, CD spectrum and analysis of its Dess-Martin oxidation derivative. Compound 1 was evaluated for antilarval settlement activity of barnacle Balanus amphitrite and showed promising antifouling activity with an EC50 value of 0.103 mu M and a high therapeutic ratio of 222. [GRAPHICS] .
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