期刊
NATURAL PRODUCT RESEARCH
卷 32, 期 12, 页码 1459-1462出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/14786419.2017.1350664
关键词
Mallotus furetianus; anti-steatosis; (Z)-3-hexenyl-beta-D-glucopyranoside; (+)-lyoniresinol-3 alpha-O-alpha-L-rhamnopyranoside; mallophenol A
There is no drug administration-approved therapy for non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH). In this study, eight compounds, gallic acid (1), methyl gallate (2), corilagin (3), 3,4,8,9,10-pentahydroxydibenzo[b,d]pyran-6-one (4), repandinin B (5), (Z)-3-hexenyl--D-glucopyranoside (6), (+)-lyoniresinol-3-O--L-rhamnopyranoside (7) and mallophenol A (8) were isolated from the active fractions of Mallotus furetianus. Three compounds, (6, 7 and 8) revealed potent anti-steatosis activity in the oleic acid (OA)-induced steatosis cell model, with the minimum effective concentration of 0.05 (6), 0.0005 (7) and 0.0005 (8) g/mL, which were much lower than the control compound, fibrate (72.4g/mL). [GRAPHICS] .
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