期刊
NATURAL PRODUCT RESEARCH
卷 32, 期 22, 页码 2652-2656出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/14786419.2017.1375924
关键词
Mangrove endophytic fungus; Aspergillus terreus; meroterpenoids; anti-inflammatory
资金
- National Natural Science Foundation of China [21472251, 41276146]
- Science & Technology Plan Project of Guangdong Province of China [2013B021100011]
- Natural Science Foundation of Guangdong Province [2016A040403091]
An unusual austinoid, 1,2-dehydro-terredehydroaustin (1), together with two known meroterpenoids (2 and 3), were isolated from the mangrove endophytic fungus Aspergillus terreus. The structures were elucidated on the basis of spectroscopic data, X-ray diffraction and ECD calculations. The anti-inflammatory activity was assayed and compound 1 exhibited weak inhibition effect against the production of nitric oxide (NO) in lipopolysaccharide (LPS)-induced RAW 246.7 mouse macrophages with an IC50 value of 42.3 mu M. [GRAPHICS]
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