期刊
NATURAL PRODUCT RESEARCH
卷 31, 期 13, 页码 1529-1535出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/14786419.2017.1280491
关键词
UPLC/Q-TOF-MS; identification; R. tanguticum; fragmentation pathways
资金
- National Natural Science Foundation of China [81102770]
- Chinese Traditional Medicine Research of Special Project [200707007]
- Technological Large Platform for Comprehensive Research and Development of New Drugs in the Twelfth Five-Year 'Significant New Drugs Created' Science and Technology Major Project [2012ZX09301-002-001-026]
- Anhui Provincial Key Project [KJ2014A051]
Rhubarb contains biologically active compounds such as anthraquinones, anthrones, stilbenes and tannins. A rapid and efficient UPLC/Q-TOF-MS/MS method was developed and applied towards identifying the constituents of Rheum tanguticum Maxim. ex Balf. for the first time. Chemical constituents were separated and investigated by UPLC/Q-TOF-MS/MS in the negative ion mode. The ESI-MS2 fragmentation pathways of four types of compounds were interpreted, providing a very useful guidance for the characterisation of different types of compounds. Based on the exact mass information, fragmentation characteristic and LC retention time of 7 reference standards, 30 constituents were tentatively identified from the methanol extract of R. tanguticum. Among them, seven compounds were described for the first time from R. tanguticum and two from the genus Rheum were described for the first time. The analytical tool used here is valuable for the rapid separation and identification of multiple and minor constituents in methanol extracts of R. tanguticum.
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