期刊
NATURAL PRODUCT RESEARCH
卷 32, 期 24, 页码 2928-2931出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/14786419.2017.1385015
关键词
Quercetin; lung cancer; receptor tyrosine kinases; molecular docking
资金
- Zayed Center for Health Sciences, United Arab Emirates University [31R015]
- United Arab Emirates University [31S156]
Lung cancer is a deadly form of cancer with high morbidity and mortality rates. Deregulated receptor tyrosine kinases (RTKs) are frequently associated with the formation and development of lung carcinoma. Quercetin is a major dietary flavonoid that has been shown to induce cell growth inhibition and apoptosis in human lung cancer cell lines. In the current study, four major overexpressed RTKs - EGFR, FGFR1, IGF1R and c-Met - involved in human lung cancer were investigated. Molecular docking was employed to identify the binding orientation and inhibitory potential of quercetin in these RTKs. Quercetin bound to the ATP binding pocket of these kinases exhibited good binding scores and interactions by establishing hydrogen, hydrophobic and pi-pi interactions with the hinge region and the DFG motif in the activation loop. Thus, quercetin could be further explored as a platform for developing specific or polypharmacological compounds targeting overexpressed RTKs in lung cancer. [GRAPHICS] .
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