期刊
NATURAL PRODUCT RESEARCH
卷 32, 期 9, 页码 1080-1087出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/14786419.2017.1380018
关键词
Piperaceae; Piper betle; chemical constituents; antioxidant; cytotoxic; SAR
资金
- CSIR (Council of Scientific and Industrial Research, New Delhi) Government of India [09/554-0030/2011 EMR-1]
The phytochemical investigation of chloroform extract from Piper betle var. haldia, Piperaceae, leaves has resulted in the isolation of two new chemical constituents which were identified as 1-n-dodecanyloxy resorcinol (H1) and desmethylenesqualenyl deoxy-cepharadione-A (H4), on the basis of spectroscopic data 1D NMR (H-1 and C-13) and 2D NMR (H-1-H-1 COSY and HMBC) as well as ESI-MS, FT-IR and HR-ESI-MS analyses. Compounds H1 and H4 showed excellent antioxidant DPPH free radical scavenging activity with IC50 values of 7.14g/mL and 8.08g/mL compared to ascorbic acid as a standard antioxidant drug with IC50 value of 2.52g/mL, respectively. Evaluation of cytotoxic activity against human hepatoma cell line (PLC-PRF-5) showed moderate effect with the GI(50) values of 35.12g/mL for H1, 31.01g/mL for H4, compared to Doxorubicin((R)) as a standard cytotoxic drug with GI(50) value of 18.80g/mL. [GRAPHICS] .
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