期刊
NATURAL PRODUCT RESEARCH
卷 32, 期 13, 页码 1573-1577出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/14786419.2017.1389934
关键词
Withania somnifera; withanolide; endophytic fungus; Taleromyces pinophilus; H-1 NMR
Withanolides, the secondary metabolite from Withania species is used in Ayurvedic medicine and now proved to have potential use in treating cardiovascular, Alzheimer's disease, etc. Its production in plants varies between genotypes with very low yield. For improved industrial commercialisation, there is a need to increase its production. Endophytic fungi are symbiotically associated with plants and can synthesise the same bioactive compounds and natural products as their host plant. There are no reports available on withanolide-producing (endophytic) fungi. The present study identified an endophytic fungus (Taleromyces pinophilus) from leaves of Withania somnifera which produces withanolides in the medium. The structure of withanolide was confirmed by H-1 NMR, LC-MS analyses and quantified by HPLC analysis. The fungus produces high amount of withanolide when compared to leaf and root of W. somnifera. The fungus can be exploited to produce the withanolide to meet its demand. [GRAPHICS] .
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