期刊
NATURAL PRODUCT RESEARCH
卷 33, 期 10, 页码 1399-1405出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/14786419.2017.1416382
关键词
Ligusticum striatum; nucleoside; alkaloids; adenosine derivatives; anti-platelet aggregation activity
资金
- Program for Comprehensive Exploitation and Regional Development of Genuine Crude Drugs of Sichuan Province [2017ZY002]
- Sichuan Science and Technology Support Program [2015SZ0031]
- Outstanding Youth Science Foundation of Sichuan Province [2015JQO030]
- Special Plan for Basic Scientific Work [2015FY111500-140]
Two new (1-2) and six known (3-8) nucleoside alkaloids were isolated from the rhizomes of Ligusticum striatum DC. Compounds 1 and 2 (liguadenosines A and B) were unusual N-10 substituted adenosine derivatives. Their structures were elucidated by extensive spectroscopic analyses and ECD calculation. Most of them significantly inhibited the abnormal increase in platelet aggregation induced by ADP at concentrations of 50 and 100 mu M. Particularly, the inhibitory effect of 3 was equivalent to aspirin.
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