期刊
NANOTECHNOLOGY
卷 28, 期 18, 页码 -出版社
IOP PUBLISHING LTD
DOI: 10.1088/1361-6528/aa66b0
关键词
theranostics; activatable; hollow mesoporous silica nanoparticles; photodynamic therapy; nearinfrared
资金
- National Research Foundation of Korea (NRF) [NRF-2015M2A2A6A01044298, 2014R1A2A1A11050923]
- National Research Foundation of Korea [2015M2A2A6A01044298, 2014R1A2A1A11050923] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Here we report indocyanine green (ICG)-loaded hollow mesoporous silica nanoparticles (ICG@HMSNP) as an activatable theranostic platform. Near-infrared fluorescence and singlet oxygen generation of ICG@HMSNP was effectively quenched (i. e. turned off) in its native state because of the fluorescence resonance energy transfer between ICG molecules. Therefore, ICG@HMSNP was nonfluorescent and nonphototoxic in the extracellular region. After the nanoparticles entered the cancer cells via endocytosis, they became highly fluorescent and phototoxic. In addition, intracellular uptake of ICG@HMSNP was 2.75 times higher than that of free ICG, resulting in an enhanced phototherapy of cancer.
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