期刊
NANOTECHNOLOGY
卷 28, 期 20, 页码 -出版社
IOP PUBLISHING LTD
DOI: 10.1088/1361-6528/aa6907
关键词
crosslinking; micelles; star-shaped copolymer; click chemistry; drug carriers
资金
- National Natural Science Foundation of China [21603196]
- Natural Science Foundation of Hubei Province [2015CFB697]
- Fundamental Research Funds for the Central Universities
- China University of Geosciences (Wuhan) [CUG170601, CUGL170406]
- State Key Laboratory of Advanced Technology for Materials Synthesis and Processing (Wuhan University of Technology)
- Shandong Eighth Institute of Geology and Mineral Resources Exploration
To balance the stability and the particle size of polymeric micelles, star-shaped copolymers Hxyne- N3-PEG containing both alkynyl and azido groups were synthesized from hyperbranched 2,2-bismethylolpropionic acid polyester (H20 with 16 hydroxyl, H30 with 32 hydroxyl, H40 with 64 hydroxyl) to develop interlayer-crosslinked micelles by click chemistry. The results of dynamic light scattering indicate that the crosslinking could enhance the stability of polymeric micelles. The crosslinked micelles are regular nanosized (approximately 20 nm) spheres observed by a transmission electron microscope. The crosslinked micelles have better drug loading capacity and more sustained drug release behavior than the un-crosslinked micelles.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据