期刊
NANOSCALE
卷 9, 期 45, 页码 17909-17913出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c7nr04919f
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资金
- MEXT, Japan [25220801, 15K05563]
- World Premier International Research Center Initiative
- Grants-in-Aid for Scientific Research [15K05563] Funding Source: KAKEN
Donor-acceptor-linked molecules have been synthesized and utilized to induce the rapid and site-selective lipid-oxidation in mitochondria by utilizing a photoinduced intermolecular electron transfer reaction. Two water-soluble donor-acceptor molecules (1 and 2) were designed and synthesized for this purpose. 2 was prepared to modulate its affinity to cell membrane in mitochondria. Confocal laser microscopy experiments revealed that 1 and 2 possess high localization abilities in mitochondria. By the photoinduced electron transfer, 2 exhibited the remarkable oxidation ability of lipids, mainly cardiolipin. In HeLa cells, 2 triggered mitochondrial lipid oxidation, which was followed by apoptotic cell death, under illumination within a few seconds. These results show that the present molecular system is highly promising to utilize the photoinduced intermolecular electron transfer reaction in a precise spatiotemporal manner in a cell by using light.
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