期刊
NANOSCALE
卷 9, 期 48, 页码 19026-19030出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c7nr06080g
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资金
- National Natural Science Foundation of China [51533006, 21374085, 21174110]
- Natural Science Foundation of Hubei Province of China [2014CFB697]
- MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Zhejiang University [2015MSF04]
- State Key Laboratory Breeding Base of Basic Science of Stomatology & Key Laboratory of Oral Biomedicine Ministry of Education, School & Hospital of Stomatology, Wuhan University [201503]
Based on boronate formation, this study reports a post-targeting methodology capable of readily installing versatile targeting modules onto a cargo-loaded nanoplatform in aqueous mediums. This permits the targeted nanodelivery of broad-spectrum therapeutics (drug/gene) in a ready-to-use manner while overcoming the PEGylation-dilemma that frequently occurs in conventional targeting approaches.
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