期刊
NANOSCALE
卷 9, 期 27, 页码 9641-9658出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c7nr02140b
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资金
- CNRS
- University of Grenoble
- University of Strasbourg Unistra
- Region Alsace
- French National Research Program for Environmental and Occupational Health of ANSES [PNREST 2015/032]
- CEA (Imaginatox grant)
- French National Research Agency [ANR-16-CE34-0011]
- Investissements d'Avenir French Government program of the French National Research Agency (ANR) through the A*MIDEX project [ANR-11-LABX-0064, ANR-11-IDEX-0001-02]
- FRISBI [ANR-10-INSB-05-02]
- GRAL within the Grenoble Partnership for Structural Biology (PSB) [ANR-10-LABX-49-01]
- French Proteomic Infrastructure (ProFI) project [ANR-10-INBS-08-03]
- Rhone-Alpes Region
- Fondation Recherche Medicale (FRM)
- fonds FEDER
- Centre National de la Recherche Scientifique (CNRS)
- CEA
- EMBL
- GIS-Infrastrutures en Biologie Sante et Agronomie (IBISA)
- Fondation pour la Recherche Medicale
- Agence Nationale de la Recherche (ANR) [ANR-16-CE34-0011] Funding Source: Agence Nationale de la Recherche (ANR)
The technological and economic benefits of engineered nanomaterials may be offset by their adverse effects on living organisms. One of the highly produced nanomaterials under such scrutiny is amorphous silica nanoparticles, which are known to have an appreciable, although reversible, inflammatory potential. This is due to their selective toxicity toward macrophages, and it is thus important to study the cellular responses of this cell type to silica nanoparticles to better understand the direct or indirect adverse effects of nanosilica. We have here studied the responses of the RAW264.7 murine macrophage cells and of the control MPC11 plasma cells to subtoxic concentrations of nanosilica, using a combination of proteomic and targeted approaches. This allowed us to document alterations in the cellular cytoskeleton, in the phagocytic capacity of the cells as well as their ability to respond to bacterial stimuli. More surprisingly, silica nanoparticles also induce a greater sensitivity of macrophages to DNA alkylating agents, such as styrene oxide, even at doses which do not induce any appreciable cell death.
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