期刊
NANOSCALE
卷 9, 期 10, 页码 3637-3645出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c7nr00231a
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资金
- National Natural Science Foundation of China [81601605, 31525009, 81501572, 61427806]
- Sichuan Innovative Research Team Program for Young Scientists [2016TD0004]
- Shenzhen Basic Research Program [JCYJ20160422091418366]
- Natural Science Foundation of SZU
- Fundamental Research Funds for the Shenzhen University, China [2016076]
- State Key Laboratory of Advanced Technology for Materials Synthesis and Processing, Wuhan University of Technology [2017-KF-6]
Nitric oxide (NO) has been well identified as a specific free radical molecule possessing wide-ranging therapeutic effects. Targeted delivery and controlled release of NO are highly desired to realize precision gas therapy, but are still challenging owing to the non-targetability and uncontrollability of NO itself. Herein, we propose a new concept of MRI-guided and ultrasound-triggered gas release for precision gas therapy. Based on this concept, we develop a novel ultrasound-responsive BNN-type NO-releasing molecule (NORM) and an advanced rattle-type nano-carrier of superparamagnetic iron oxide-encapsulated mesoporous silica nanoparticles (SPION@hMSN), and use them to construct a new intelligent nano-medicine (BNN6-SPION@hMSN) for the first time. The BNN6-SPION@hMSN nanomedicine exhibits excellent passive tumor-targeting capability, high MRI-guided tumor localization performance and a unique ultrasound-triggered NO release profile. The tumor-targeted, MRI-guided and ultrasound-triggered release profiles of the developed nanomedicine enable the tumor site-specific controlled release of NO in favor of high-efficacy and safe NO gas therapy of tumor.
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