期刊
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
卷 13, 期 6, 页码 2037-2048出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.nano.2017.04.013
关键词
Atherosclerosis; NF-kappa B; Foam cells; Fullerenes; Low-density lipoprotein
资金
- [1R01GM083274-01C]
- [R21 ESO15696-01A]
- [NCBC 2012 BRG1203]
The transformation of monocyte-derived macrophages into lipid-laden foam cells is one inflammatory process underlying atherosclerotic disease. Previous studies have demonstrated that fullerene derivatives (FDs) have inflammation-blunting properties. Thus, it was hypothesized that FD could inhibit the transformation process underlying foam cell formation. Fullerene derivatives inhibited the phorbolmyristic acid/oxidized low-density lipoprotein-induced differentiation of macrophages into foam cells as determined by lipid staining and morphology. Lipoproteininduced generation of TNF-alpha, C5a-induced MC activation, ICAM-1 driven adhesion, and CD36 expression were significantly inhibited in FD treated cells compared to non-treated cells. Inhibition appeared to bemediated through theNF-kappa Bpathway as FDreduced expression ofNF-kappa Band atherosclerosis-associated genes. Compared to controls, FDdramatically inhibited plaque formation in arteries of apolipoprotein E null mice. Thus, FD may be an unrecognized therapy to prevent atherosclerotic lesions via inhibition of foam cell formation and MC stabilization. (C) 2017 Elsevier Inc. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据