期刊
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
卷 13, 期 4, 页码 1435-1445出版社
ELSEVIER
DOI: 10.1016/j.nano.2017.01.016
关键词
Electrospun nanofibers; Co-delivery; Suture; Anti-bacterial; Surgical site infections
资金
- University of Nebraska Medical Center
- National Institute of General Medical Science (NIGMS) [2P20 GM103480-06]
- Otis Glebe Medical Research Foundation
Surgical site infections (SSIs) represent the most common nosocomial infection among surgical patients. In order to prevent SSIs in a sustained manner and lessen side effects, we developed a twisting method for generation of nanofiber-based sutures capable of simultaneous delivery of silver and gentamicin. The prepared sutures are composed of core-sheath nanofibers with gentamicin/pluronic F127 in the core and silver/PCL in the sheath produced by co-axial electrospinning. The diameters of obtained sutures range from similar to 80 mu m to similar to 1.2 mm. The in vitro release profiles of silver and gentamicin exhibit an initial burst followed by a sustained release over 5 weeks. The co-encapsulated sutures were able to kill bacteria much more effectively than gentamicin or silver alone loaded nanofiber sutures, without showing obvious impact on proliferation and migration of dermal fibroblasts and keratinocytes. The gentamicin and silver co-loaded PCL nanofiber sutures may hold great potential for prevention of SSIs. (C) 2017 Elsevier Inc. All rights reserved.
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