期刊
NANOMEDICINE
卷 12, 期 2, 页码 117-129出版社
FUTURE MEDICINE LTD
DOI: 10.2217/nnm-2016-0308
关键词
doxorubicin carrier; drug resistance; semi-interpenetrated PNIPAM
资金
- Bundesministerium fur Bildung und Forschung (BMBF) through the NanoMatFutur award (ThermoNanogele) [13N12561]
- Helmholtz Virtual Institute Multifunctional Biomaterials for Medicine
- Freie Universitat Berlin Focus Area Nanoscale
- Alexander von Humboldt Foundation
Aim: To develop nanogels (NG) able to modulate the encapsulation and release of drugs, in order to circumvent drug resistance mechanisms in cancer cells. Materials & methods: Poly-N-isopropylacrylamide-dendritic polyglycerol NG were semi-interpenetrated with 2-acrylamido-2-methylpropane sulfonic acid or (2-dimethylamino) ethyl metha-crylate. Physico-chemical properties of the NGs as well as doxorubicin (DOXO) loading and release were characterized. Drug delivery performance was investigated in vitro and in vivo in a multidrug-resistant tumor model. Results: Both the DOXO loaded semi-interpenetrating polymer network NGs were more efficient in multidrug resistant cancer cell proliferation inhibition studies. In vivo, the DOXO loaded NG semi-interpenetrated with 2-acrylamido-2-methylpropane sulfonic acid was able to overcome drug resistance and reduce the tumor volume to about 25%. Conclusion: The innovative semi-interpenetrating polymer network NGs appear to be promising drug carriers for drug resistant cancer therapy.
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