期刊
NANOMEDICINE
卷 12, 期 4, 页码 333-356出版社
FUTURE MEDICINE LTD
DOI: 10.2217/nnm-2016-0336
关键词
cellular uptake; hyperlipidemia; nanomedicine; phospholipid; Quality by Design; targeting
资金
- University Grant Commission (UGC), New Delhi, India, under its RFSMS (BSR) scheme [5-94/2007[BSR]]
Aim: The present studies describe Quality by Design-oriented development and characterization of surface-engineered solid lipid nanoparticles (SLNs) of rosuvastatin calcium for low density lipoprotein-receptor targeting. Materials & methods: SLNs were systematically prepared employing Compritol 888 and Tween-80. Surface modification of SLNs was accomplished with Phospholipon 90G and DSPE-mPEG-2000 as the ligands for specific targeting to the low density lipoprotein-receptors. SLNs were evaluated for size, potential, entrapment, drug release performance and gastric stability. Also, the formulations were evaluated for cellular cytotoxicity, uptake and permeability, pharmacokinetic, pharmacodynamic and biochemical studies. Results & conclusion: Overall, the studies ratified enhanced biopharmaceutical performance of the surface-engineered SLNs of rosuvastatin as a novel approach for the management of hyperlipidemia-like conditions.
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