期刊
NANOMEDICINE
卷 12, 期 15, 页码 1851-1872出版社
FUTURE MEDICINE LTD
DOI: 10.2217/nnm-2017-0011
关键词
beta-carotene; bioavailability; breast cancer; lipid polymer hybrid nanoparticles; methotrexate; toxicity
资金
- Jaswant Singh Gill Pharma research fellowship, ICAR, New Delhi, India
- DST-SERB, New Delhi, India
- UGC, New Delhi, India
- technical education quality improvement program (teqip) Phase II
Aim: This work was intended to investigate the targeting potential of fructose-tethered lipid-polymeric hybrid nanoparticles (F-BC-MTX-LPHNPs) co-loaded with beta carotene (BC) and methotrexate (MTX) in breast cancer therapeutics and find out the possible protective role of BC on MTX-induced toxicity. Materials & methods: F-BC-MTX-LPHNPs were fabricated using self-assembled nano-precipitation technique. Fructose was conjugated on the surface of the particles. The in vitro cytotoxicity, sub-cellular localization and apoptotic activity of F-BC-MTX-LPHNPs were evaluated against MCF-7 breast cancer cells. The antitumor potential of F-BC-MTX-LPHNPs was further studied. Results & conclusion: Outcomes suggested that F-BC-MTX-LPHNPs induced the highest apoptosis index (0.89) against MCF-7 cells. Following 30 days of treatment, the residual tumor progression was assessed to be approximately 32%, in animals treated with F-BC-MTX-LPHNPs. F-BC-MTX-LPHNPs are competent to selectively convey the chemotherapeutic agent to the breast cancers. Beta carotene ameliorated MTX-induced hepatic and renal toxicity.
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