Targeted therapy of octreotide-modified oleanolic acid liposomes to somatostatin receptor overexpressing tumor cells

Aim: To prepare and validate the efficacy of a novel targeted drug delivery system octreotide (Oct)-modified oleanolic acid (OA) liposomes. Materials & methods: OA liposomes (OA-L) were prepared by an ethanol injection method. The Oct-modified OA liposomes (O-OA-L) were synthesized and their properties were evaluated. Cellular uptake and competition inhibition studies were performed. Results: The OA vesicles presented satisfactory particles size (100-200 nm), stability and drug release characteristics; their. potential was -1.42 +/- 0.08 mV. The O-OA-L had a higher cell proliferation inhibitory activity and cellular uptake than that of OA-L for somatostatin receptor-positive A549 cells. Conclusion: The O-OA-L, as a promising agent, can target actively the lesion site with safe and high-efficiency pattern.