期刊
NANOMEDICINE
卷 12, 期 8, 页码 927-940出版社
FUTURE MEDICINE LTD
DOI: 10.2217/nnm-2017-0009
关键词
antitumor activity; octreotide; oleanolic acid; somatostatin receptor; targeting transportation
资金
- National Natural Science Foundation [21476190]
- Hebei Province Key Basic Research fund [15961301D]
- Hebei Province Science and Technology Support Project [142777118D]
- Qinhuangdao Science and Technology Research and Development Project [201202B029]
Aim: To prepare and validate the efficacy of a novel targeted drug delivery system octreotide (Oct)-modified oleanolic acid (OA) liposomes. Materials & methods: OA liposomes (OA-L) were prepared by an ethanol injection method. The Oct-modified OA liposomes (O-OA-L) were synthesized and their properties were evaluated. Cellular uptake and competition inhibition studies were performed. Results: The OA vesicles presented satisfactory particles size (100-200 nm), stability and drug release characteristics; their. potential was -1.42 +/- 0.08 mV. The O-OA-L had a higher cell proliferation inhibitory activity and cellular uptake than that of OA-L for somatostatin receptor-positive A549 cells. Conclusion: The O-OA-L, as a promising agent, can target actively the lesion site with safe and high-efficiency pattern.
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