期刊
NANOMEDICINE
卷 12, 期 7, 页码 777-795出版社
FUTURE MEDICINE LTD
DOI: 10.2217/nnm-2016-0397
关键词
learning and memory; neurotoxicity; oxidative stress; prenatal exposure; ZnO nanoparticles
资金
- National Natural Science Foundation of China [81550011]
- Natural Science Foundation of Guang-dong Province of China [2015A030313299]
- Zhejiang Provincial Natural Science Foundation of China [LY16H140003]
- Wenzhou Municipal Science and Technology Bureau Foundation of China [Y20150070]
To examine the neurotoxicity of prenatal exposure to ZnO nanoparticles on rat offspring. Materials & methods: Pregnant Sprague-Dawley rats were exposed to ZnO nanoparticles (NPs) by gavage. Toxicity was assessed including zinc biodistribution, cerebral histopathology, antioxidant status and learning and memory capability. Results: A significantly elevated concentration of zinc was detected in offspring brains. Transmission electron microscope observations showed abnormal neuron ultrastructures. Histopathologic changes such as decreased proliferation and higher apoptotic death were observed. An obvious imbalanced antioxidant status occurred in brains. Adult experimental offspring exhibited impaired learning and memory behavior in the Morris water maze test compared with control groups. Conclusion: These adverse effects on offspring brain may cause impaired learning and memory capabilities in adulthood, particularly in female rats.
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