期刊
NANOMEDICINE
卷 12, 期 5, 页码 443-456出版社
FUTURE MEDICINE LTD
DOI: 10.2217/nnm-2016-0384
关键词
breast cancer; nanographene oxide; PEGylated Vitamin E; phototherapy; TPGS
资金
- FEDER funds through the POCI - COMPETE - Operational Programme Competitiveness and Internationalization in Axis I - Strengthening research, technological development and innovation [POCI-01-0145-FEDER-007491]
- National Funds by FCT - Foundation for Science and Technology [UID/Multi/00709/2013]
- FCT [SFRH/BD/103506/2014, SFRH/BD/103507/2014]
Aim: To evaluate the therapeutic capacity of D-alpha-tocopheryl polyethylene glycol 1000 succinate (TPGS)-functionalized nanographene oxide (nGO) in breast cancer cells. Methods: TPGS-functionalized nGO-based materials were obtained through two different approaches: a simple sonication method and a one-pot hydrothermal treatment. Results: TPGS coating successfully improved the stability of the nGO-based materials. The nanomaterials that underwent the hydrothermal procedure generated a 1.4- to 1.6- fold higher temperature variation under near infrared laser irradiation than those prepared only by sonication. In vitro, the TPGS/nGO derivatives reduced breast cancer cells' viability and had an insignificant effect on healthy cells. Furthermore, the combined application of TPGS/nGO derivatives and near infrared light generated an improved therapeutic effect. Conclusion: TPGS/nGO derivatives are promising materials for breast cancer phototherapy.
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