期刊
NANOMEDICINE
卷 12, 期 4, 页码 403-416出版社
FUTURE MEDICINE LTD
DOI: 10.2217/nnm-2016-0342
关键词
cerium oxide nanoparticles; bioenergetic dysfunction; mitochondria
资金
- Italian Space Agency [2016-7-U.0]
Aim: Owing to their catalytic properties as reactive oxygen species scavengers, cerium oxide nanoparticles (nanoceria) have become an extremely promising candidate for medical applications, especially in the treatment of diseases where oxidative stress has been proposed as one of the main pathogenesis factors. Materials & methods: In this work, nanoceria antioxidant power has been tested in primary cultured skin fibroblasts, derived from healthy individuals, by evaluating the mitochondrial function both in basal condition and after an oxidative insult. Results & conclusion: Combined with a clear lack of toxicity, antioxidant activity makes nanoceria promising in a wide range of clinical applications sharing the common signature of a global bioenergetic dysfunction.
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