期刊
NANO TODAY
卷 14, 期 -, 页码 16-41出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.nantod.2017.04.006
关键词
Protein self-assembly; Supramolecular nanostructures; Protein-protein interactions; Bioinspired materials; Hierarchical construction
资金
- National Natural Science Foundation of China [21234004, 21420102007, 21574056, 91527302]
- Chang Jiang Scholars Program of China
Sophisticated protein self-assemblies have attracted great scientific interests in recent few decades due to their various potential applications in substance/signal transmission, biosensors, or disease diagnosis and treatment. The design and construction of proteins into hierarchical nanostructures via self-assembly strategies offer unique advantages in understanding the mechanism of naturally occurring protein assemblies and/or creating various functional biomaterials with advanced properties. This review covers the recent progress and trends in the self-assembled hierarchical protein structures and their bio-inspired applications. We initially discuss the design and development of sophisticated protein nanostructures through the preciously designed protein-protein interactions. Many intricate protein nanostructures from quasi-zero dimensional (OD) polyhedral cages, one-dimensional (1D) strings/rings/tubules, two-dimensional (2D) crystal sheets/cambered surfaces, and three-dimensional (3D) crystalline frameworks/hydrogels, have been constructed through self-assembly of rationally designed proteins. In addition, we also show the representative achievements in the study of the structure-function relationship for selected protein self-assemblies and highlight the latest research progress in developing artificial light harvesting systems, biological nanoenzyme mimics, intelligent protein nanocarriers, biomimetic protocells, and so on. As expected, protein self-assembly has become a powerful tool for development of multifarious bioinspired materials with advanced structures and properties. (C) 2017 Elsevier Ltd. All rights reserved.
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