期刊
NANO LETTERS
卷 17, 期 2, 页码 652-659出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.nanolett.6b03517
关键词
Neuromodulation; focused ultrasound; nanoparticles; gated drug release
类别
资金
- NIH [NIBIB R01EB016721, R01EB022148, NICHD R21HD073105, NCI P50CA058236, NCI F31CA214147]
- Philips Inc.
- Foundation of the American Society for Neuroradiology
- Walter and Mary Ciceric Foundation
- Achievement Rewards for College Scientists Metro-DC Chapter
- National Science Foundation [DGE-1232825]
Targeted, noninvasive neuromodulation of the brain of an otherwise awake subject could revolutionize both basic and clinical neuroscience. Toward this goal, we have developed nanoparticles that allow noninvasive uncaging of a neuromodulatory drug, in this case the small molecule anesthetic propofol, upon the application of focused ultrasound. These nanoparticles are composed of biodegradable and biocompatible constituents and are activated using sonication parameters that are readily achievable by current clinical transcranial focused ultrasound systems. These particles are potent enough that their activation can silence seizures in an acute rat seizure model. Notably, there is no evidence of brain parenchymal damage or blood brain barrier opening with their use. Further development of these particles promises noninvasive, focal, and image-guided clinical neuromodulation along a variety of pharmacological axes.
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