期刊
NANO LETTERS
卷 17, 期 12, 页码 7283-7288出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.nanolett.7b02787
关键词
DNA nanotechnology; nucleic acids; dynamic self-assembly; pH; active scaffolds
类别
资金
- Associazione Italiana per la Ricerca sul Cancro, AIRC [14420]
- European Research Council, ERC [336493]
- Italian Ministry of Education, University and Research (PRIN)
- U.S. Department of Energy, Office of Science, Office of Basic Energy Sciences [DESC0010595]
- European Research Council (ERC) [336493] Funding Source: European Research Council (ERC)
Inspired by cytoskeletal scaffolds that sense and respond dynamically to environmental changes and chemical inputs with a unique capacity for reconfiguration, we propose a strategy that allows the dynamic and reversible control of the growth and breakage of micron scale synthetic DNA structures upon pH changes. We do so by,rationally designing a pH-responsive system composed of synthetic DNA strands that act as pH sensors, regulators, and structural elements. Sensor strands can dynamically respond to pH changes and route regulatory strands to direct the self-assembly of structural elements into tubular structures. This example represents the first demonstration of the reversible assembly and disassembly of micron-scale DNA scaffolds using an external chemical input other than DNA. The capacity to reversibly modulate nanostructure size may promote the development of smart devices for catalysis or drug-delivery applications.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据